Characterization of TelE, a T7SS LXG effector exhibiting a conserved C-terminal glycine zipper motif required for toxicity

• Main Authors: Teh, Wooi Keong, Ding, Yichen, Gubellini, Francesca, Filloux, Alain, Poyart, Claire, Givskov, Michael, Dramsi, Shaynoor
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Environmental engineering; Streptococcus Gallolyticus; Pore-forming Toxin
• Online Access: https://hdl.handle.net/10356/171665
• Institution: Nanyang Technological University

Streptococcus gallolyticus subsp. gallolyticus (SGG) is an opportunistic bacterial pathogen strongly associated with colorectal cancer. Here, through comparative genomics analysis, we demonstrated that the genetic locus encoding the type VIIb secretion system (T7SSb) machinery is uniquely present in...