Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor

• Main Authors: Chia, Wan Ni, Tan, Chee Wah, Tan, Aaron Wai Kit, Young, Barnaby, Starr, Tyler N., Lopez, Ester, Fibriansah, Guntur, Barr, Jennifer, Cheng, Samuel, Yeoh, Aileen Ying-Yan, Yap, Wee Chee, Lim, Beng Lee, Ng, Thiam-Seng, Sia, Wan Rong, Zhu, Feng, Chen, Shiwei, Zhang, Jinyan, Kwek, Madeline Sheng Si, Greaney, Allison J., Chen, Mark, Au, Gough G., Paradkar, Prasad N., Peiris, Malik, Chung, Amy W., Bloom, Jesse D., Lye, David, Lok, Sheemei, Wang, Lin-Fa
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Cryo-Electron Microscopy; Human Monoclonal Antibodies
• Online Access: https://hdl.handle.net/10356/171764
• Institution: Nanyang Technological University

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern such as Omicron hampered efforts in controlling the ongoing coronavirus disease 2019 pandemic due to their ability to escape neutralizing antibodies induced by vaccination or prior infection, highlighti...