The cytoplasmic domain of the SARS-CoV-2 envelope protein assembles into a β-sheet bundle in lipid bilayers

• Main Authors: Dregni, Aurelio J., McKay, Matthew J., Surya, Wahyu, Queralt-Martin, Maria, Medeiros-Silva, João, Wang, Harrison K., Aguilella, Vicente, Torres, Jaume, Hong, Mei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Biological sciences; Membrane Curvature; Oligomerization
• Online Access: https://hdl.handle.net/10356/171791
• Institution: Nanyang Technological University

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein forms a pentameric ion channel in the lipid membrane of the endoplasmic reticulum Golgi intermediate compartment (ERGIC) of the infected cell. The cytoplasmic domain of E interacts with host proteins to cause virus...