Photoactivatable nanoagonists chemically programmed for pharmacokinetic tuning and in situ cancer vaccination

• Main Authors: Wan, Jianqin, Ren, Lulu, Li, Xiaoyan, He, Shasha, Fu, Yang, Xu, Peirong, Meng, Fanchao, Xian, Shiyun, Pu, Kanyi, Wang, Hangxiang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Pharmacokinetic Tuning; Prodrug Design
• Online Access: https://hdl.handle.net/10356/171814
• Institution: Nanyang Technological University

Immunotherapy holds great promise for the treatment of aggressive and metastatic cancers; however, currently available immunotherapeutics, such as immune checkpoint blockade, benefit only a small subset of patients. A photoactivatable toll-like receptor 7/8 (TLR7/8) nanoagonist (PNA) system that imp...