APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia

• Main Authors: Vipin, Ashwati, Kumar, Dilip, Soo, See Ann, Zailan, Fatin Zahra, Leow, Yi Jin, Koh, Chen Ling, Ng, Adeline Su Lyn, Ng, Kok Pin, Kandiah, Nagaendran
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; White Matter Hyperintensity; Dementia
• Online Access: https://hdl.handle.net/10356/172169
• Institution: Nanyang Technological University

White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs furth...