Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood

Background: Longitudinal assessment of the determinants of obesogenic growth trajectories in childhood can suggest appropriate developmental windows for intervention. Methods: Latent class growth mixture modelling was used to identify body mass index (BMI) z-score trajectories from birth to age 6 ye...

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Main Authors: Michael, Navin, Gupta, Varsha, Fogel, Anna, Huang, Jonathan, Chen, Li, Sadananthan, Suresh Anand, Ong, Yi Ying, Aris, Izzuddin M., Pang, Wei Wei, Yuan, Wen Lun, Loy, See Ling, Tint, Mya Thway, Tan, Kok Hian, Chan, Jerry Ky, Chan, Shiao-Yng, Shek, Lynette Pei-Chi, Yap, Fabian, Godfrey, Keith, Chong, Yap Seng, Gluckman, Peter, Velan, S. Sendhil, Forde, Ciarán G., Lee, Yung Seng, Eriksson, Johan G., Karnani, Neerja
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2023
Subjects:
Online Access:https://hdl.handle.net/10356/172443
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Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-172443
record_format dspace
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Childhood Obesity
Growth Trajectories
spellingShingle Science::Medicine
Childhood Obesity
Growth Trajectories
Michael, Navin
Gupta, Varsha
Fogel, Anna
Huang, Jonathan
Chen, Li
Sadananthan, Suresh Anand
Ong, Yi Ying
Aris, Izzuddin M.
Pang, Wei Wei
Yuan, Wen Lun
Loy, See Ling
Tint, Mya Thway
Tan, Kok Hian
Chan, Jerry Ky
Chan, Shiao-Yng
Shek, Lynette Pei-Chi
Yap, Fabian
Godfrey, Keith
Chong, Yap Seng
Gluckman, Peter
Velan, S. Sendhil
Forde, Ciarán G.
Lee, Yung Seng
Eriksson, Johan G.
Karnani, Neerja
Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
description Background: Longitudinal assessment of the determinants of obesogenic growth trajectories in childhood can suggest appropriate developmental windows for intervention. Methods: Latent class growth mixture modelling was used to identify body mass index (BMI) z-score trajectories from birth to age 6 years in 994 children from a prospective mother–offspring cohort (Chinese, Indian and Malay ethnicities) based in Singapore. We evaluated the early-life determinants of the trajectories as well as their associations with cardiometabolic risk markers at age 6 years. Results: Five BMI z-score trajectory patterns were identified, three within the healthy weight range, alongside early-acceleration and late-acceleration obesogenic trajectories. The early-acceleration pattern was characterized by elevated fetal abdominal circumference growth velocity, BMI acceleration immediately after birth and crossing of the obesity threshold by age 2 years. The late-acceleration pattern had normal fetal growth and BMI acceleration after infancy, and approached the obesity threshold by age 6 years. Abdominal fat, liver fat, insulin resistance and odds of pre-hypertension/hypertension were elevated in both groups. Indian ethnicity, high pre-pregnancy BMI, high polygenic risk scores for obesity and shorter breastfeeding duration were common risk factors for both groups. Malay ethnicity and low maternal educational attainment were uniquely associated with early BMI acceleration, whereas nulliparity and obesogenic eating behaviours in early childhood were uniquely associated with late BMI acceleration. Conclusion: BMI acceleration starting immediately after birth or after infancy were both linked to early cardiometabolic alterations. The determinants of these trajectories may be useful for developing early risk stratification and intervention approaches to counteract metabolic adversities linked to childhood obesity.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Michael, Navin
Gupta, Varsha
Fogel, Anna
Huang, Jonathan
Chen, Li
Sadananthan, Suresh Anand
Ong, Yi Ying
Aris, Izzuddin M.
Pang, Wei Wei
Yuan, Wen Lun
Loy, See Ling
Tint, Mya Thway
Tan, Kok Hian
Chan, Jerry Ky
Chan, Shiao-Yng
Shek, Lynette Pei-Chi
Yap, Fabian
Godfrey, Keith
Chong, Yap Seng
Gluckman, Peter
Velan, S. Sendhil
Forde, Ciarán G.
Lee, Yung Seng
Eriksson, Johan G.
Karnani, Neerja
format Article
author Michael, Navin
Gupta, Varsha
Fogel, Anna
Huang, Jonathan
Chen, Li
Sadananthan, Suresh Anand
Ong, Yi Ying
Aris, Izzuddin M.
Pang, Wei Wei
Yuan, Wen Lun
Loy, See Ling
Tint, Mya Thway
Tan, Kok Hian
Chan, Jerry Ky
Chan, Shiao-Yng
Shek, Lynette Pei-Chi
Yap, Fabian
Godfrey, Keith
Chong, Yap Seng
Gluckman, Peter
Velan, S. Sendhil
Forde, Ciarán G.
Lee, Yung Seng
Eriksson, Johan G.
Karnani, Neerja
author_sort Michael, Navin
title Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
title_short Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
title_full Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
title_fullStr Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
title_full_unstemmed Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
title_sort longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood
publishDate 2023
url https://hdl.handle.net/10356/172443
_version_ 1787136763763884032
spelling sg-ntu-dr.10356-1724432023-12-11T01:17:12Z Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood Michael, Navin Gupta, Varsha Fogel, Anna Huang, Jonathan Chen, Li Sadananthan, Suresh Anand Ong, Yi Ying Aris, Izzuddin M. Pang, Wei Wei Yuan, Wen Lun Loy, See Ling Tint, Mya Thway Tan, Kok Hian Chan, Jerry Ky Chan, Shiao-Yng Shek, Lynette Pei-Chi Yap, Fabian Godfrey, Keith Chong, Yap Seng Gluckman, Peter Velan, S. Sendhil Forde, Ciarán G. Lee, Yung Seng Eriksson, Johan G. Karnani, Neerja Lee Kong Chian School of Medicine (LKCMedicine) Duke-NUS Medical School KK Women’s and Children’s Hospital Science::Medicine Childhood Obesity Growth Trajectories Background: Longitudinal assessment of the determinants of obesogenic growth trajectories in childhood can suggest appropriate developmental windows for intervention. Methods: Latent class growth mixture modelling was used to identify body mass index (BMI) z-score trajectories from birth to age 6 years in 994 children from a prospective mother–offspring cohort (Chinese, Indian and Malay ethnicities) based in Singapore. We evaluated the early-life determinants of the trajectories as well as their associations with cardiometabolic risk markers at age 6 years. Results: Five BMI z-score trajectory patterns were identified, three within the healthy weight range, alongside early-acceleration and late-acceleration obesogenic trajectories. The early-acceleration pattern was characterized by elevated fetal abdominal circumference growth velocity, BMI acceleration immediately after birth and crossing of the obesity threshold by age 2 years. The late-acceleration pattern had normal fetal growth and BMI acceleration after infancy, and approached the obesity threshold by age 6 years. Abdominal fat, liver fat, insulin resistance and odds of pre-hypertension/hypertension were elevated in both groups. Indian ethnicity, high pre-pregnancy BMI, high polygenic risk scores for obesity and shorter breastfeeding duration were common risk factors for both groups. Malay ethnicity and low maternal educational attainment were uniquely associated with early BMI acceleration, whereas nulliparity and obesogenic eating behaviours in early childhood were uniquely associated with late BMI acceleration. Conclusion: BMI acceleration starting immediately after birth or after infancy were both linked to early cardiometabolic alterations. The determinants of these trajectories may be useful for developing early risk stratification and intervention approaches to counteract metabolic adversities linked to childhood obesity. Agency for Science, Technology and Research (A*STAR) National Medical Research Council (NMRC) The study is supported by the National Medical Research Council, Singapore (NMRC) (NMRC/TCR/004-NUS/2008, NMRC/TCR/ 012-NUHS/2014, OFLCG19May-0033) and Singapore Institute for Clinical Sciences (SICS), Agency for Science Technology and Research, Singapore (A*STAR). N.K. is supported by A*STAR National Health and Medical Research Council, Australia (NHMRC) joint call funding (1711624031). K.M.G. is supported by the UK Medical Research Council (UK MRC) (MC_UU_12011/ 4), National Institute for Health Research (NF-SI-0515–10042 and IS-BRC-1215–20004), European Union (Erasmusþ Programme ImpENSA 598488-EPP-1–2018-1-DE-EPPKA2-CBHE-JP), British Heart Foundation (RG/15/17/3174) and US National Institutes of Health’s National Institute On Aging (award no. U24AG047867). 2023-12-11T01:17:12Z 2023-12-11T01:17:12Z 2023 Journal Article Michael, N., Gupta, V., Fogel, A., Huang, J., Chen, L., Sadananthan, S. A., Ong, Y. Y., Aris, I. M., Pang, W. W., Yuan, W. L., Loy, S. L., Tint, M. T., Tan, K. H., Chan, J. K., Chan, S., Shek, L. P., Yap, F., Godfrey, K., Chong, Y. S., ...Karnani, N. (2023). Longitudinal characterization of determinants associated with obesogenic growth patterns in early childhood. International Journal of Epidemiology, 52(2), 426-439. https://dx.doi.org/10.1093/ije/dyac177 0300-5771 https://hdl.handle.net/10356/172443 10.1093/ije/dyac177 36087338 2-s2.0-85152970991 2 52 426 439 en NMRC/TCR/004-NUS/2008 NMRC/TCR/ 012-NUHS/2014 OFLCG19May-0033 International Journal of Epidemiology © 2022 The Author(s). All rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.