Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis
Background: Recent studies suggest that tirzepatide, a dual glucose-dependent insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has significant weight loss effects. This systematic review and meta-analysis aims to assess the efficacy and safety of tirzepatide for...
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sg-ntu-dr.10356-1724622023-12-11T05:04:27Z Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis Tan, Bryan Pan, Xin-Hui Chew, Jocelyn Han Shi Goh, Rachel Sze Jen Lin, Chaoxing Anand, Vickram Vijay Lee, Ethan Cheng Zhe Chan, Kai En Kong, Gwyneth Ong, Christen En Ya Chung, Charlotte Hui Young, Dan Yock Chan, Mark Y. Khoo, Chin Meng Mehta, Anurag Muthiah, Mark Dhinesh Noureddin, Mazen Ng, Cheng Han Chew, Nicholas W. S. Chin, Yip Han Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Tirzepatide Obesity; Background: Recent studies suggest that tirzepatide, a dual glucose-dependent insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has significant weight loss effects. This systematic review and meta-analysis aims to assess the efficacy and safety of tirzepatide for weight loss in patients with overweight or obesity. Methods: Medline, Embase and Cochrane CENTRAL were searched for randomized controlled trials (RCTs) on tirzepatide’s weight loss efficacy for these patients. A single arm meta-analysis of proportions estimated primary outcomes, ≥5%, ≥10%, and ≥15% weight loss, and adverse events (AEs); while meta-analysis of means estimated secondary outcomes. Comparative meta-analysis was conducted between tirzepatide and control arms where mean differences and odds ratios were estimated for continuous and dichotomous outcomes respectively. Results: RCTs included in this study revealed that among 5800 patients, 78.22% (95% CI: 72.15% to 83.73%), 55.60% (95% CI: 46.54% to 64.47%), 32.28% (95% CI: 23.17% to 42.12%) achieved ≥5%, ≥10%, and ≥15% weight loss, respectively. Tirzepatide 5 mg demonstrated weight loss superiority relative to placebo (MD: −12.47 kg, 95% CI: −13.94 kg to −11.00 kg) and semaglutide (n = 1409, MD: −1.90 kg, 95% CI: −2.97 kg to −0.83 kg) with dose-dependent increase for 10 mg and 15 mg doses. The comparison between tirzepatide and semaglutide was examined in the SURPASS-2 trial that was included in this systematic review. For AEs, there was increase odds of experiencing gastrointestinal AEs with tirzepatide compared to placebo, but no significant difference with semaglutide. Conclusion: Tirzepatide has significant potential as a weight loss drug in patients with overweight and obesity, with little increase in AEs compared to other weight loss drugs. With its ability to concurrently target multiple aspects of metabolic syndrome, it should be considered as the next helm of weight loss therapies. MYC: Speaker’s fees and research grants Astra Zeneca, Abbott Technologies and Boston Scientific. MN: MN has been on the advisory board for 89BIO, Gilead, Intercept, Pfizer, Novo Nordisk, Blade, EchoSens, Fractyl, Terns, Siemens and Roche diagnostic; he has received research support from Allergan, BMS, Gilead, Galmed, Galectin, Genfit, Conatus, Enanta, Madrigal, Novartis, Pfizer, Shire, Viking and Zydus; he is a minor shareholder or has stocks in Anaetos, Rivus Pharma and Viking. 2023-12-11T05:04:27Z 2023-12-11T05:04:27Z 2023 Journal Article Tan, B., Pan, X., Chew, J. H. S., Goh, R. S. J., Lin, C., Anand, V. V., Lee, E. C. Z., Chan, K. E., Kong, G., Ong, C. E. Y., Chung, C. H., Young, D. Y., Chan, M. Y., Khoo, C. M., Mehta, A., Muthiah, M. D., Noureddin, M., Ng, C. H., Chew, N. W. S. & Chin, Y. H. (2023). Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis. International Journal of Obesity, 47(8), 677-685. https://dx.doi.org/10.1038/s41366-023-01321-5 0307-0565 https://hdl.handle.net/10356/172462 10.1038/s41366-023-01321-5 37253796 2-s2.0-85160663656 8 47 677 685 en International Journal of Obesity © 2023 The Author(s), under exclusive licence to Springer Nature Limited. All rights reserved. |
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Science::Medicine Tirzepatide Obesity; Tan, Bryan Pan, Xin-Hui Chew, Jocelyn Han Shi Goh, Rachel Sze Jen Lin, Chaoxing Anand, Vickram Vijay Lee, Ethan Cheng Zhe Chan, Kai En Kong, Gwyneth Ong, Christen En Ya Chung, Charlotte Hui Young, Dan Yock Chan, Mark Y. Khoo, Chin Meng Mehta, Anurag Muthiah, Mark Dhinesh Noureddin, Mazen Ng, Cheng Han Chew, Nicholas W. S. Chin, Yip Han Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis |
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Background: Recent studies suggest that tirzepatide, a dual glucose-dependent insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has significant weight loss effects. This systematic review and meta-analysis aims to assess the efficacy and safety of tirzepatide for weight loss in patients with overweight or obesity. Methods: Medline, Embase and Cochrane CENTRAL were searched for randomized controlled trials (RCTs) on tirzepatide’s weight loss efficacy for these patients. A single arm meta-analysis of proportions estimated primary outcomes, ≥5%, ≥10%, and ≥15% weight loss, and adverse events (AEs); while meta-analysis of means estimated secondary outcomes. Comparative meta-analysis was conducted between tirzepatide and control arms where mean differences and odds ratios were estimated for continuous and dichotomous outcomes respectively. Results: RCTs included in this study revealed that among 5800 patients, 78.22% (95% CI: 72.15% to 83.73%), 55.60% (95% CI: 46.54% to 64.47%), 32.28% (95% CI: 23.17% to 42.12%) achieved ≥5%, ≥10%, and ≥15% weight loss, respectively. Tirzepatide 5 mg demonstrated weight loss superiority relative to placebo (MD: −12.47 kg, 95% CI: −13.94 kg to −11.00 kg) and semaglutide (n = 1409, MD: −1.90 kg, 95% CI: −2.97 kg to −0.83 kg) with dose-dependent increase for 10 mg and 15 mg doses. The comparison between tirzepatide and semaglutide was examined in the SURPASS-2 trial that was included in this systematic review. For AEs, there was increase odds of experiencing gastrointestinal AEs with tirzepatide compared to placebo, but no significant difference with semaglutide. Conclusion: Tirzepatide has significant potential as a weight loss drug in patients with overweight and obesity, with little increase in AEs compared to other weight loss drugs. With its ability to concurrently target multiple aspects of metabolic syndrome, it should be considered as the next helm of weight loss therapies. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Tan, Bryan Pan, Xin-Hui Chew, Jocelyn Han Shi Goh, Rachel Sze Jen Lin, Chaoxing Anand, Vickram Vijay Lee, Ethan Cheng Zhe Chan, Kai En Kong, Gwyneth Ong, Christen En Ya Chung, Charlotte Hui Young, Dan Yock Chan, Mark Y. Khoo, Chin Meng Mehta, Anurag Muthiah, Mark Dhinesh Noureddin, Mazen Ng, Cheng Han Chew, Nicholas W. S. Chin, Yip Han |
format |
Article |
author |
Tan, Bryan Pan, Xin-Hui Chew, Jocelyn Han Shi Goh, Rachel Sze Jen Lin, Chaoxing Anand, Vickram Vijay Lee, Ethan Cheng Zhe Chan, Kai En Kong, Gwyneth Ong, Christen En Ya Chung, Charlotte Hui Young, Dan Yock Chan, Mark Y. Khoo, Chin Meng Mehta, Anurag Muthiah, Mark Dhinesh Noureddin, Mazen Ng, Cheng Han Chew, Nicholas W. S. Chin, Yip Han |
author_sort |
Tan, Bryan |
title |
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis |
title_short |
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis |
title_full |
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis |
title_fullStr |
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis |
title_full_unstemmed |
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis |
title_sort |
efficacy and safety of tirzepatide for treatment of overweight or obesity. a systematic review and meta-analysis |
publishDate |
2023 |
url |
https://hdl.handle.net/10356/172462 |
_version_ |
1787136785390764032 |