YWHAG deficiency disrupts the EMT-associated network to induce oxidative cell death and prevent metastasis

• Main Authors: Lee, Jeannie Xue Ting, Tan, Wei Ren, Low, Zun Siong, Lee, Jia Qi, Chua, Damien, Yeo, Wisely Duan Chi, See, Benedict, Vos, Marcus Ivan Gerard, Yasuda, Tomohiko, Nomura, Sachiyo, Cheng, Hong Sheng, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Biological sciences; Autophagy; Epithelial-Mesenchymal Transition
• Online Access: https://hdl.handle.net/10356/173115
• Institution: Nanyang Technological University

Metastasis involves epithelial-to-mesenchymal transition (EMT), a process that is regulated by complex gene networks, where their deliberate disruption may yield a promising outcome. However, little is known about mechanisms that coordinate these metastasis-associated networks. To address this gap,...