Physical forces guide curvature sensing and cell migration mode bifurcating

• Main Authors: Feng, Luyi, Zhao, Tiankai, Xu, Hongmei, Shi, Xuechen, Li, Changhao, Hsia, K. Jimmy, Zhang, Sulin
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering::Bioengineering; Engineering::Mechanical engineering; Surface Tension; Molecular Flow
• Online Access: https://hdl.handle.net/10356/173169
• Institution: Nanyang Technological University

The ability of cells to sense and adapt to curvy topographical features has been implicated in organ morphogenesis, tissue repair, and tumor metastasis. However, how individual cells or multicellular assemblies sense and differentiate curvatures remains elusive. Here, we reveal a curvature sensing m...