Semiconducting polymer nanospherical nucleic acid probe for transcriptomic imaging of cancer chemo-immunotherapy

• Main Authors: Xu, Cheng, Yu, Jie, Ning, Xiaoyu, Xu, Mengke, He, Shasha, Wu, Jiayan, Pu, Kanyi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; Engineering::Bioengineering; Cancer Immunotherapy; Fluorescence Imaging
• Online Access: https://hdl.handle.net/10356/173281
• Institution: Nanyang Technological University

Real-time in vivo imaging of RNA can enhance the understanding of physio-pathological processes. However, most nucleic acid-based sensors have poor resistance to nucleases and limited photophysical properties, making them suboptimal for this purpose. To address this, a semiconducting polymer nanosph...