Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants

Titanium-based alloys exhibit superior resistance to corrosion and biocompatibility in comparison to other alloys utilized for implant applications, such as stainless steel and cobalt-based alloys. Nonetheless, no completely inert metal is suitable for implantation in the human body, as aseptic loos...

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Main Authors: Lin, Yu-Chien, Hu, Chih-Chien, Nguyen, Thu-Trang, Dhawan, Udesh, Chou, Ching-Yi, Lee, Yueh-Lien, Yen, Hung-Wei, Kuo, Yi-Jie, Chung, Ren-Jei
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/173678
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1736782024-02-23T15:45:51Z Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants Lin, Yu-Chien Hu, Chih-Chien Nguyen, Thu-Trang Dhawan, Udesh Chou, Ching-Yi Lee, Yueh-Lien Yen, Hung-Wei Kuo, Yi-Jie Chung, Ren-Jei School of Materials Science and Engineering Engineering Orthopedic implants Electrochemical hydrogen storage Titanium-based alloys exhibit superior resistance to corrosion and biocompatibility in comparison to other alloys utilized for implant applications, such as stainless steel and cobalt-based alloys. Nonetheless, no completely inert metal is suitable for implantation in the human body, as aseptic loosening of the implant or the release of ions in the vicinity of the implant can result in inflammation and implant failure. Therefore, the primary objective of this study was to employ hydrogenated titanium 6-aluminum-4-vanadium (H–Ti6Al4V) alloy to reduce reactive oxygen species (ROS) and thereby achieve the function of regulating inflammatory signaling when employed as an implant. The Ti6Al4V alloy was successfully hydrogenated using a cathodic hydrogen-charging method. The H–Ti6Al4V alloy displayed a surface Young's modulus 33.97 ± 9.21 GPa similar to that of trabecular bone (∼22.3 GPa) and notably lower hardness (3.32 ± 0.62 GPa) than the Ti6Al4V alloy (21.79 ± 2.42 GPa). In vitro and in vivo investigations indicated that the H–Ti6Al4V alloy did not negatively affect bone-related cells and triggered minimal inflammatory responses in Sprague–Dawley rats. Moreover, reduced ROS production was observed around the H–Ti6Al4V alloys, confirming that hydrogenation could effectively counteract the ROS generated during cell metabolism and indirectly impede the inflammatory response around the prosthesis, thereby rendering it a promising metallic implant for the treatment of bone defects. Published version The authors are grateful for the financial support received from the National Science and Technology Council of Taiwan (MOST 108-2628-E−027-003-MY3; MOST 109-2224-E−002-002); and the National Taipei University of Technology and Chang Gung Memorial Hospital Joint Research Program (NTUT-CGMH-111-01 [CORPG3M0191]). 2024-02-21T08:10:39Z 2024-02-21T08:10:39Z 2024 Journal Article Lin, Y., Hu, C., Nguyen, T., Dhawan, U., Chou, C., Lee, Y., Yen, H., Kuo, Y. & Chung, R. (2024). Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants. Journal of Materials Research and Technology, 28, 1504-1513. https://dx.doi.org/10.1016/j.jmrt.2023.12.066 2238-7854 https://hdl.handle.net/10356/173678 10.1016/j.jmrt.2023.12.066 2-s2.0-85179884531 28 1504 1513 en Journal of Materials Research and Technology © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering
Orthopedic implants
Electrochemical hydrogen storage
spellingShingle Engineering
Orthopedic implants
Electrochemical hydrogen storage
Lin, Yu-Chien
Hu, Chih-Chien
Nguyen, Thu-Trang
Dhawan, Udesh
Chou, Ching-Yi
Lee, Yueh-Lien
Yen, Hung-Wei
Kuo, Yi-Jie
Chung, Ren-Jei
Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
description Titanium-based alloys exhibit superior resistance to corrosion and biocompatibility in comparison to other alloys utilized for implant applications, such as stainless steel and cobalt-based alloys. Nonetheless, no completely inert metal is suitable for implantation in the human body, as aseptic loosening of the implant or the release of ions in the vicinity of the implant can result in inflammation and implant failure. Therefore, the primary objective of this study was to employ hydrogenated titanium 6-aluminum-4-vanadium (H–Ti6Al4V) alloy to reduce reactive oxygen species (ROS) and thereby achieve the function of regulating inflammatory signaling when employed as an implant. The Ti6Al4V alloy was successfully hydrogenated using a cathodic hydrogen-charging method. The H–Ti6Al4V alloy displayed a surface Young's modulus 33.97 ± 9.21 GPa similar to that of trabecular bone (∼22.3 GPa) and notably lower hardness (3.32 ± 0.62 GPa) than the Ti6Al4V alloy (21.79 ± 2.42 GPa). In vitro and in vivo investigations indicated that the H–Ti6Al4V alloy did not negatively affect bone-related cells and triggered minimal inflammatory responses in Sprague–Dawley rats. Moreover, reduced ROS production was observed around the H–Ti6Al4V alloys, confirming that hydrogenation could effectively counteract the ROS generated during cell metabolism and indirectly impede the inflammatory response around the prosthesis, thereby rendering it a promising metallic implant for the treatment of bone defects.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Lin, Yu-Chien
Hu, Chih-Chien
Nguyen, Thu-Trang
Dhawan, Udesh
Chou, Ching-Yi
Lee, Yueh-Lien
Yen, Hung-Wei
Kuo, Yi-Jie
Chung, Ren-Jei
format Article
author Lin, Yu-Chien
Hu, Chih-Chien
Nguyen, Thu-Trang
Dhawan, Udesh
Chou, Ching-Yi
Lee, Yueh-Lien
Yen, Hung-Wei
Kuo, Yi-Jie
Chung, Ren-Jei
author_sort Lin, Yu-Chien
title Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
title_short Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
title_full Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
title_fullStr Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
title_full_unstemmed Study on surface hydrogenated Ti6Al4V alloy for orthopedic implants
title_sort study on surface hydrogenated ti6al4v alloy for orthopedic implants
publishDate 2024
url https://hdl.handle.net/10356/173678
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