Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study

OBJECTIVES: We examined whether pericardial adipose tissue (PAT) is predictive of prediabetes and type 2 diabetes over time. METHODS: In total, 2,570 adults without prediabetes/diabetes from the Coronary Artery Risk Development in Young Adults Study were followed up over 15 years. PAT volume was mea...

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Main Authors: Oh, Minsuk, Cho, Wonhee, Lee, Dong Hoon, Whitaker, Kara M., Schreiner, Pamela J., Terry, James G., Kim, Joon Young
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/173720
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spelling sg-ntu-dr.10356-1737202024-03-03T15:38:36Z Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study Oh, Minsuk Cho, Wonhee Lee, Dong Hoon Whitaker, Kara M. Schreiner, Pamela J. Terry, James G. Kim, Joon Young Lee Kong Chian School of Medicine (LKCMedicine) Medicine, Health and Life Sciences Adipose tissue Obesity OBJECTIVES: We examined whether pericardial adipose tissue (PAT) is predictive of prediabetes and type 2 diabetes over time. METHODS: In total, 2,570 adults without prediabetes/diabetes from the Coronary Artery Risk Development in Young Adults Study were followed up over 15 years. PAT volume was measured by computed tomography scans, and the new onset of prediabetes/diabetes was examined 5 years, 10 years, and 15 years after the PAT measurements. Multivariable Cox regression models were used to examine the association between the tertile of PAT and incident prediabetes/diabetes up to 15 years later. The predictive ability of PAT (vs. waist circumference [WC], body mass index [BMI], waist-to-height ratio [WHtR]) for prediabetes/diabetes was examined by comparing the area under the receiver operating characteristic curve (AUC). RESULTS: The highest tertile of PAT was associated with a 1.56 times (95% confidence interval [CI], 1.03 to 2.34) higher rate of diabetes than the lowest tertile; however, no association was found between the highest tertile of PAT and prediabetes in the fully adjusted models, including additional adjustment for BMI or WC. In the fully adjusted models, the AUCs of WC, BMI, WHtR, and PAT for predicting diabetes were not significantly different, whereas the AUC of WC for predicting prediabetes was higher than that of PAT. CONCLUSIONS: PAT may be a significant predictor of hyperglycemia, but this association might depend on the effect of BMI or WC. Additional work is warranted to examine whether novel adiposity indicators can suggest advanced and optimal information to supplement the established diagnosis for prediabetes/diabetes. Published version The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I & HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). 2024-02-26T00:42:38Z 2024-02-26T00:42:38Z 2023 Journal Article Oh, M., Cho, W., Lee, D. H., Whitaker, K. M., Schreiner, P. J., Terry, J. G. & Kim, J. Y. (2023). Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study. Epidemiology and Health, 45, e2023001-. https://dx.doi.org/10.4178/epih.e2023001 2092-7193 https://hdl.handle.net/10356/173720 10.4178/epih.e2023001 36550747 2-s2.0-85150079356 45 e2023001 en Epidemiology and Health © 2023 Korean Society of Epidemiology. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Medicine, Health and Life Sciences
Adipose tissue
Obesity
spellingShingle Medicine, Health and Life Sciences
Adipose tissue
Obesity
Oh, Minsuk
Cho, Wonhee
Lee, Dong Hoon
Whitaker, Kara M.
Schreiner, Pamela J.
Terry, James G.
Kim, Joon Young
Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
description OBJECTIVES: We examined whether pericardial adipose tissue (PAT) is predictive of prediabetes and type 2 diabetes over time. METHODS: In total, 2,570 adults without prediabetes/diabetes from the Coronary Artery Risk Development in Young Adults Study were followed up over 15 years. PAT volume was measured by computed tomography scans, and the new onset of prediabetes/diabetes was examined 5 years, 10 years, and 15 years after the PAT measurements. Multivariable Cox regression models were used to examine the association between the tertile of PAT and incident prediabetes/diabetes up to 15 years later. The predictive ability of PAT (vs. waist circumference [WC], body mass index [BMI], waist-to-height ratio [WHtR]) for prediabetes/diabetes was examined by comparing the area under the receiver operating characteristic curve (AUC). RESULTS: The highest tertile of PAT was associated with a 1.56 times (95% confidence interval [CI], 1.03 to 2.34) higher rate of diabetes than the lowest tertile; however, no association was found between the highest tertile of PAT and prediabetes in the fully adjusted models, including additional adjustment for BMI or WC. In the fully adjusted models, the AUCs of WC, BMI, WHtR, and PAT for predicting diabetes were not significantly different, whereas the AUC of WC for predicting prediabetes was higher than that of PAT. CONCLUSIONS: PAT may be a significant predictor of hyperglycemia, but this association might depend on the effect of BMI or WC. Additional work is warranted to examine whether novel adiposity indicators can suggest advanced and optimal information to supplement the established diagnosis for prediabetes/diabetes.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Oh, Minsuk
Cho, Wonhee
Lee, Dong Hoon
Whitaker, Kara M.
Schreiner, Pamela J.
Terry, James G.
Kim, Joon Young
format Article
author Oh, Minsuk
Cho, Wonhee
Lee, Dong Hoon
Whitaker, Kara M.
Schreiner, Pamela J.
Terry, James G.
Kim, Joon Young
author_sort Oh, Minsuk
title Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
title_short Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
title_full Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
title_fullStr Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
title_full_unstemmed Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
title_sort long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
publishDate 2024
url https://hdl.handle.net/10356/173720
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