Immunotherapy targeting isoDGR-protein damage extends lifespan in a mouse model of protein deamidation

• Main Authors: Kalailingam, Pazhanichamy, Mohd-Kahliab, Khalilatul-Hanisah, Ngan, SoFong Cam, Iyappan, Ranjith, Melekh, Evelin, Lu, Tian, Zien, Gan Wei, Sharma, Bhargy, Guo, Tiannan, MacNeil, Adam J., MacPherson, Rebecca Ek, Tsiani, Evangelia Litsa, O'Leary, Deborah D., Lim, Kah-Leong, Su, I Hsin, Gao, Yong-Gui, Richards, A. Mark, Kalaria, Raj N., Chen, Christopher P., McCarthy, Neil E., Sze, Siu Kwan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Immunotherapy; Inflammation
• Online Access: https://hdl.handle.net/10356/173773
• Institution: Nanyang Technological University

Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age-linked damage to amino acid sequence NGR (Asn-Gly-Arg) results in "gain-of-function" conformational switching to isoDGR (isoAsp-Gly-Arg). This integrin-binding...