Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis
Mindfulness has become increasingly popular and the practice presents in many different forms. Research has been growing extensively with benefits shown across various outcomes. However, there is a lack of consensus over the efficacy of randomized controlled mindfulness interventions, both tradition...
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sg-ntu-dr.10356-1738562024-03-10T15:30:21Z Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis Siew, Savannah Kiah Hui Yu, Junhong School of Social Sciences Social Sciences Diagnostic imaging Mindfulness Mindfulness has become increasingly popular and the practice presents in many different forms. Research has been growing extensively with benefits shown across various outcomes. However, there is a lack of consensus over the efficacy of randomized controlled mindfulness interventions, both traditional and mind-body formats. This study aimed to investigate the structural brain changes in mindfulness-based interventions through a meta-analysis. Scopus, PubMed, Web of Science, and PsycINFO were searched up to April 2023. 11 studies (n = 581) assessing whole-brain voxel-based grey matter or cortical thickness changes after a mindfulness RCT were included. Anatomical likelihood estimation was used to carry out voxel-based meta-analysis with leave-one-out sensitivity analysis and behavioural analysis as follow-ups. One significant cluster (p < 0.001, Z = 4.76, cluster size = 632 mm3) emerged in the right insula and precentral gyrus region (MNI = 48, 10, 4) for structural volume increases in intervention group compared to controls. Behavioural analysis revealed that the cluster was associated with mental processes of attention and somesthesis (pain). Mindfulness interventions have the ability to affect neural plasticity in areas associated with better pain modulation and increased sustained attention. This further cements the long-term benefits and neuropsychological basis of mindfulness-based interventions. Nanyang Technological University Published version We would like to acknowledge the Nanyang Assistant Professorship (Award no. 021080-00001) grant. 2024-03-04T01:22:46Z 2024-03-04T01:22:46Z 2023 Journal Article Siew, S. K. H. & Yu, J. (2023). Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis. Scientific Reports, 13(1), 18469-. https://dx.doi.org/10.1038/s41598-023-45765-1 2045-2322 https://hdl.handle.net/10356/173856 10.1038/s41598-023-45765-1 37891243 2-s2.0-85175147659 1 13 18469 en 021080-00001 Scientific Reports © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
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Social Sciences Diagnostic imaging Mindfulness Siew, Savannah Kiah Hui Yu, Junhong Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
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Mindfulness has become increasingly popular and the practice presents in many different forms. Research has been growing extensively with benefits shown across various outcomes. However, there is a lack of consensus over the efficacy of randomized controlled mindfulness interventions, both traditional and mind-body formats. This study aimed to investigate the structural brain changes in mindfulness-based interventions through a meta-analysis. Scopus, PubMed, Web of Science, and PsycINFO were searched up to April 2023. 11 studies (n = 581) assessing whole-brain voxel-based grey matter or cortical thickness changes after a mindfulness RCT were included. Anatomical likelihood estimation was used to carry out voxel-based meta-analysis with leave-one-out sensitivity analysis and behavioural analysis as follow-ups. One significant cluster (p < 0.001, Z = 4.76, cluster size = 632 mm3) emerged in the right insula and precentral gyrus region (MNI = 48, 10, 4) for structural volume increases in intervention group compared to controls. Behavioural analysis revealed that the cluster was associated with mental processes of attention and somesthesis (pain). Mindfulness interventions have the ability to affect neural plasticity in areas associated with better pain modulation and increased sustained attention. This further cements the long-term benefits and neuropsychological basis of mindfulness-based interventions. |
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School of Social Sciences |
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School of Social Sciences Siew, Savannah Kiah Hui Yu, Junhong |
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Siew, Savannah Kiah Hui Yu, Junhong |
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Siew, Savannah Kiah Hui |
title |
Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
title_short |
Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
title_full |
Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
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Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
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Mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
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mindfulness-based randomized controlled trials led to brain structural changes: an anatomical likelihood meta-analysis |
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2024 |
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https://hdl.handle.net/10356/173856 |
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1794549293858684928 |