Alterations to DNA methylation patterns induced by chemotherapy treatment are associated with negative impacts on the olfactory pathway

• Main Authors: Ho, Peh Joo, Khng, Alexis Jiaying, Tan, Benita Kiat-Tee, Lim, Geok Hoon, Tan, Su-Ming, Tan, Veronique Kiak Mien, Tan, Ryan Shea Ying Cong, Lim, Elaine Hsuen, Iau, Philip Tsau-Choong, Chew, Ying Jia, Lim, Yi Ying, Hartman, Mikael, Tan, Ern Yu, Li, Jingmei
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2024
• 主題: Medicine, Health and Life Sciences; Epigenetic modifcation; Breast cancer
• 在線閱讀: https://hdl.handle.net/10356/173869
• 機構: Nanyang Technological University

Background: Exposure to cytotoxic chemotherapy treatment may alter DNA methylation (DNAm) in breast cancer patients. Methods: We performed DNAm analysis in 125 breast cancer patients with blood drawn before and after chemotherapy, using the Illumina MethylationEPIC array. DNAm changes of 588,798 ind...