MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria parasites remain elusive. We developed a sequence-based, ab initio deep learning framework, MalariaSED, for predicting chromatin profiles in malaria pa...

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Bibliographic Details
Main Authors: Wang, Chengqi, Dong, Yibo, Li, Chang, Oberstaller, Jenna, Zhang, Min, Gibbons, Justin, Pires, Camilla Valente, Xiao, Mianli, Zhu, Lei, Jiang, Rays H. Y., Kim, Kami, Miao, Jun, Otto, Thomas D., Cui, Liwang, Adams, John H., Liu, Xiaoming
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Malaria
Parasites
Online Access:https://hdl.handle.net/10356/173875
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Institution: Nanyang Technological University
Language: English
Description
Summary:Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria parasites remain elusive. We developed a sequence-based, ab initio deep learning framework, MalariaSED, for predicting chromatin profiles in malaria parasites. The MalariaSED performance was validated by published ChIP-qPCR and TF motifs results. Applying MalariaSED to ~ 1.3 million variants shows that geographically differentiated noncoding variants are associated with parasite invasion and drug resistance. Further analysis reveals chromatin accessibility changes at Plasmodium falciparum rings are partly associated with artemisinin resistance. MalariaSED illuminates the potential functional roles of noncoding variants in malaria parasites.

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