Machine learning-based detection of adventitious microbes in T-cell therapy cultures using long-read sequencing

• المؤلفون الرئيسيون: Strutt, James P. B., Natarajan, Meenubharathi, Lee, Elizabeth, Teo, Denise Bei Lin, Sin, Wei-Xiang, Cheung, Ka-Wai, Chew, Marvin, Thazin, Khaing, Barone, Paul W., Wolfrum, Jacqueline M., Williams, Rohan B. H., Rice, Scott A., Springs, Stacy L.
• مؤلفون آخرون: Singapore-MIT Alliance for Research and Technology
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Adventitious agents; Machine learning
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/173925
• المؤسسة: Nanyang Technological University

Assuring that cell therapy products are safe before releasing them for use in patients is critical. Currently, compendial sterility testing for bacteria and fungi can take 7-14 days. The goal of this work was to develop a rapid untargeted approach for the sensitive detection of microbial contaminant...