Upper limb sensorimotor recovery in Asian stroke survivors: a study protocol for the development and implementation of a technology-assisted digitaL biomarker (TAILOR) platform

• Main Authors: Cheng, Hsiao-Ju, Chin, Lay Fong, Kanzler, Christoph M., Lehner, Rea, Kuah, Christopher Wee Keong, Kager, Simone, Josse, Eva, Samkharadze, Tengiz, Sidarta, Ananda, Gonzalez, Pablo Cruz, Lie, Eloise, Zbytniewska-Mégret, Monika, Wee, Seng Kwee, Liang, Phyllis, Gassert, Roger, Chua, Karen, Lambercy, Olivier, Wenderoth, Nicole
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Stroke; Neurorehabilitation
• Online Access: https://hdl.handle.net/10356/173973
• Institution: Nanyang Technological University

Stroke is a leading cause of lifelong disability worldwide, partially driven by a reduced ability to use the upper limb in daily life causing increased dependence on caregivers. However, post-stroke functional impairments have only been investigated using limited clinical scores, during short-term longitudinal studies in relatively small patient cohorts. With the addition of technology-based assessments, we propose to complement clinical assessments with more sensitive and objective measures that could more holistically inform on upper limb impairment recovery after stroke, its impact on upper limb use in daily life, and on overall quality of life. This paper describes a pragmatic, longitudinal, observational study protocol aiming to gather a uniquely rich multimodal database to comprehensively describe the time course of upper limb recovery in a representative cohort of 400 Asian adults after stroke. Particularly, we will characterize the longitudinal relationship between upper limb recovery, common post-stroke impairments, functional independence and quality of life.