Tougher bioadhesives through dual stimulation strategies

Tougher bioadhesives through dual stimulation strategies

Carbene based bioadhesives have favourable attributes for tissue adhesion, including non-specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene-precursor (diazirine) also creates inert side products that are absent u...

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Bibliographic Details
Main Authors: Ang, Elwin Wei Jian, Djordjevic, Ivan, Solic, Ivan, Goh, Chen Yee, Steele, Terry W. J.
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2024
Subjects:
Engineering
Other
Polycaprolactone
Diazirine
Carbene
Bioadhesive
Dual-activation
Rheology
Nuclear magnetic resonance spectroscopy
Online Access:https://hdl.handle.net/10356/174221
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Institution: Nanyang Technological University
Language: English
Description
Summary:Carbene based bioadhesives have favourable attributes for tissue adhesion, including non-specific bonding to wet and dry tissues, but suffer from relatively weak fracture strength after photocuring. Light irradiation of carbene-precursor (diazirine) also creates inert side products that are absent under thermal activation. Herein, a dual activation method combines light irradiation at elevated temperatures for the evaluation of diazirine depletion and effects on cohesive properties. A customized photo/thermal-rheometer evaluates viscoelastic properties, correlated to the kinetics of carbene:diazoalkane ratios via 19F NMR. The latter exploits the sensitive -CF3 functional group to determine joule-based light/temperature kinetics on trifluoroaryl diazirine consumption. The combination of heat and photoactivation produced bioadhesives that are 3x tougher compared to control. Dual thermal/light irradiation may be a strategy to improve viscoelastic dissipation and toughness of photo-activated adhesive resins.

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