GlcNAc-1,6-anhydro-MurNAc moiety affords unusual glycosyl acceptor that terminates peptidoglycan elongation

• المؤلفون الرئيسيون: Zhang, Xiao-Lin, Báti, Gábor, Li, Chenyu, Guo, Aoxin, Yeo, Claresta, Ding, Han, Pal, Kumar Bhaskar, Xu, Yuan, Qiao, Yuan, Liu, Xue-Wei
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Chemistry; Medicine, Health and Life Sciences; Anhydromuropeptide; Glycosylation; Glycosyl acceptor; Enzymes; Transglycosylase
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/174229
• المؤسسة: Nanyang Technological University

Peptidoglycan (PG), an essential exoskeletal polymer in bacteria, is a well-known antibiotic target. PG polymerization requires the action of bacterial transglycosylases (TGases), which couple the incoming glycosyl acceptor to the donor. Interfering with the TGase activity can interrupt the PG assem...