Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases

• Main Authors: Liang, Yaquan, Zhao, Yilin, Kwan, Jeric Mun Chung, Wang, Yue, Qiao, Yuan
• 其他作者: School of Chemistry, Chemical Engineering and Biotechnology
• 格式: Article
• 語言: English
• 出版: 2024
• 主題: Medicine, Health and Life Sciences; Cell wall; Peptidoglycan
• 在線閱讀: https://hdl.handle.net/10356/174231
• 機構: Nanyang Technological University

Peptidoglycan (PG) is an essential and conserved exoskeletal component in all bacteria that protects cells from lysis. Gram-negative bacteria such as Escherichia coli encode multiple redundant lytic transglycosylases (LTs) that engage in PG cleavage, a potentially lethal activity requiring proper re...