Mechanistic insights into the activities of major families of enzymes in bacterial peptidoglycan assembly and breakdown

• المؤلفون الرئيسيون: Kwan, Jeric Mun Chung, Qiao, Yuan
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Engineering::Bioengineering; Biosynthesis; Enzymes
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/166214
• المؤسسة: Nanyang Technological University

Serving as an exoskeletal scaffold, peptidoglycan is a polymeric macromolecule that is essential and conserved across all bacteria, yet is absent in mammalian cells; this has made bacterial peptidoglycan a well-established excellent antibiotic target. In addition, soluble peptidoglycan fragments der...