Mechanistic insights into the activities of major families of enzymes in bacterial peptidoglycan assembly and breakdown

• Main Authors: Kwan, Jeric Mun Chung, Qiao, Yuan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Biosynthesis; Enzymes
• Online Access: https://hdl.handle.net/10356/166214
• Institution: Nanyang Technological University

Serving as an exoskeletal scaffold, peptidoglycan is a polymeric macromolecule that is essential and conserved across all bacteria, yet is absent in mammalian cells; this has made bacterial peptidoglycan a well-established excellent antibiotic target. In addition, soluble peptidoglycan fragments der...