Design and enantioselective synthesis of chiral pyranone fused indole derivatives with antibacterial activities against Xanthomonas oryzae pv oryzae for protection of rice

• Main Authors: Teng, Kunpeng, Liu, Qian, Zhang, Meng, Naz, Hira, Zheng, Pengcheng, Wu, Xingxing, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Agricultural Sciences; Chiral indole derivatives; Bacterial activity
• Online Access: https://hdl.handle.net/10356/174249
• Institution: Nanyang Technological University

A new class of chiral pyranone fused indole derivatives were prepared by means of N-heterocyclic carbene (NHC) organocatalysis and demonstrated notable antibacterial activity against Xanthomonas oryzae pv oryzae (Xoo). Bioassays showed that compounds (3S,4R)-5b, (3S,4R)-5d, and (3S,4R)-5l exhibited...