Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice

• Main Authors: Li, Qing, Chan, Hung, Liu, Wei-Xin, Liu, Chang-An, Zhou, Yunfei, Huang, Dan, Wang, Xueliang, Li, Xiaoxing, Xie, Chuan, Liu, Wing Ying-Zhi, Wang, Xian-Song, Ng, Siu Kin, Gou, Hongyan, Zhao, Liu-Yang, Fong, Winnie, Jiang, Lanping, Lin, Yufeng, Zhao, Guijun, Bai, Feihu, Liu, Xiaodong, Chen, Huarong, Zhang, Lin, Wong, Sunny Hei, Chan, Matthew Tak Vai, Wu, William Ka Kei, Yu, Jun
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Colon cancer; Estrogen
• Online Access: https://hdl.handle.net/10356/174259
• Institution: Nanyang Technological University

Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific manner. Estrogen increases the attachment and colonization of C. m...