CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma

• Main Authors: Chuah, You Heng, Tay, Emmy Xue Yun, Grinchuk, Oleg V., Yoon, Jeehyun, Feng, Jia, Kannan, Srinivasaraghavan, Robert, Matius, Jakhar, Rekha, Liang, Yajing, Lee, Bernice Woon Li, Wang, Loo Chien, Lim, Yan Ting, Zhao, Tianyun, Sobota, Radoslaw M., Lu, Guang, Low, Boon Chuan, Crasta, Karen Carmelina, Verma, Chandra Shekhar, Lin, Zhewang, Ong, Derrick Sek Tong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; CAMK2D protein; Glioma
• Online Access: https://hdl.handle.net/10356/174262
• Institution: Nanyang Technological University

MAD2 is a spindle assembly checkpoint protein that participates in the formation of mitotic checkpoint complex, which blocks mitotic progression. RNF8, an established DNA damage response protein, has been implicated in mitotic checkpoint regulation but its exact role remains poorly understood. Here,...