KR4SL: knowledge graph reasoning for explainable prediction of synthetic lethality

• Main Authors: Zhang, Ke, Wu, Min, Liu, Yong, Feng, Yimiao, Zheng, Jie
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Computer and Information Science; Automated pattern recognition; Drug delivery system
• Online Access: https://hdl.handle.net/10356/174266
• Institution: Nanyang Technological University

Motivation: Synthetic lethality (SL) is a promising strategy for anticancer therapy, as inhibiting SL partners of genes with cancer-specific mutations can selectively kill the cancer cells without harming the normal cells. Wet-lab techniques for SL screening have issues like high cost and off-target...