Unveiling the influence of tumor microenvironment and spatial heterogeneity on temozolomide resistance in glioblastoma using an advanced human in vitro model of the blood-brain barrier and glioblastoma

• Main Authors: Lam, Maxine S. Y., Aw, Joey J. Y., Tan, Damien, Vijayakumar, Ragavi, Lim, Grace Hui Yi, Yada, Swathi, Pang, Qing You, Barker, Nick, Tang, Carol, Ang, Beng Ti, Sobota, Radoslaw M., Pavesi, Andrea
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Blood-brain barrier; Chemoresistance
• Online Access: https://hdl.handle.net/10356/174305
• Institution: Nanyang Technological University

Glioblastoma (GBM) is the most common primary malignant brain cancer in adults with a dismal prognosis. Temozolomide (TMZ) is the first-in-line chemotherapeutic; however, resistance is frequent and multifactorial. While many molecular and genetic factors have been linked to TMZ resistance, the role...