Unravelling mitochondrial impairment in spinocerebellar ataxia 3: insights from neuroblastoma cells and human induced pluripotent stem cells

• Main Author: Ong, Lisa Helen
• Other Authors: Valerie Lin
• Format: Thesis-Master by Research
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences; Spinocerebellar ataxia 3; Mitochondrial impairment; Human induced pluripotent stem cells
• Online Access: https://hdl.handle.net/10356/174347
• Institution: Nanyang Technological University

Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by the abnormal CAG repeat expansion in the ATXN3 gene, resulting in an expanded polyglutamine tract within the ataxin-3 protein. Despite significant progress in comprehending SCA3 etiology, the underlying disease mechanisms...