Rheology and luer lock application study of all-natural diamine-based bioadhesive

• Main Author: Chin, Tiffany Jing En
• Other Authors: Terry W.J. Steele
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Chemistry; Bioadhesive
• Online Access: https://hdl.handle.net/10356/174645
• Institution: Nanyang Technological University

Suturing is a medical technique used for wound closure that is widely used in medical settings, such as hospitals and clinics as a common procedure. However, traditional suturing has many drawbacks like infection risks, invasiveness, and tissue damage. Bioadhesive may be an alternative to suturing. Benefits include faster closure and better aesthetic outcomes. Polyamine-based (putrescine) bioadhesive demonstrate sufficient shear strength, and adhesion on soft tissues. However, the adhesive’s viscosity remains too high for application within luer-lock syringes. This project aims to replace and optimize putrescine in order to lower viscosity but retain adhesive performances. Four additional polyamines (diaminopyrimidine, propane diamine, butyraldehyde, PEG-Diamine) are selected and evaluated for their structure-property relationships. Rheological tests evaluate the dynamic viscosity before screening in luer-lock system for bioadhesive applications. Diaminopyrimidine may be a suitable alternative to putrescine. It has a lower viscosity of 4.3 ± 3.5 Pa.s at 24°C while retaining the storage modulus of 33.6 kPa at 37°C compared to putrescine adhesives. Diaminopyrimidine is also able to mix within a luer lock easily, providing a homogenously mixed adhesive for application purpose.