High-throughput microfluidic extraction of platelet-free plasma for MicroRNA and extracellular vesicle analysis

• Main Authors: Leong, Sheng Yuan, Lok, Wan Wei, Goh, Kah Yee, Ong, Hong Boon, Tay, Hui Min, Su, Chengxun, Kong, Fang, Upadya, Megha, Wang, Wei, Radnaa, Enkhtuya, Menon, Ramkumar, Dao, Ming, Dalan, Rinkoo, Suresh, Subra, Lim, Darren Wan-Teck, Hou, Han Wei
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Platelet-free plasma; Liquid biopsy
• Online Access: https://hdl.handle.net/10356/174668
• Institution: Nanyang Technological University

Cell-free RNAs and extracellular vesicles (EVs) are valuable biomarkers in liquid biopsies, but they are prone to preanalytical variabilities such as nonstandardized centrifugation or ex vivo blood degradation. Herein, we report a high-throughput and label-free inertial microfluidic device (ExoArc)...