Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer
Frequent intravesical chemotherapy is still the adopted clinical option after bladder cancer surgery with low adhesion, poor selectivity, low permeability, and drug resistance. Herein, we develop an ingenious bladder cancer dissociation method to enhance intravesical chemotherapy and tumor self-excl...
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sg-ntu-dr.10356-1747042024-04-12T15:32:01Z Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer Ma, Zhaoyu Sun, Zhiduo Ye, Zhichao Cai, Kai Zhong, Wenbin Yuan, Wei Zhang W. Zhang, Weiyun Zhang, Jin Liang, Huageng Han, Heyou Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Chemistry Deep penetration Tumor dissociation Frequent intravesical chemotherapy is still the adopted clinical option after bladder cancer surgery with low adhesion, poor selectivity, low permeability, and drug resistance. Herein, we develop an ingenious bladder cancer dissociation method to enhance intravesical chemotherapy and tumor self-exclusion with urine. Ethylene diamine tetraacetic acid (EDTA), a common Ca2+ chelator, is loaded with the typical clinical bladder instillation drug doxorubicin (Dox) in chitosan-modified hollow gold nanorods and subsequently coated with cancer cell membranes. After bladder perfusion, the nanoplatform exhibits high affinity toward bladder tumors under homologous targeting, assisting in long-term retention. Under NIR-II laser irradiation, the photothermal effect accelerates the unloading of cargo, and the released EDTA then disrupts intratumoral junctions by depriving and chelating Ca2+ from the intercellular calcium-dependent connexin. The consequential intertumoral dissociation gives access to the deeper penetration of Dox and allows the exclusion of the shed small tumor masses from the body with the urine. This distinctive tumor dissociation concept holds great promise for modern clinical intravesical chemotherapy and perhaps for other gastrointestinal malignancies. National Research Foundation (NRF) Published version National Natural Science Foundation of China, Grant/Award Numbers: 12174136,81927807; National Research Foundation Singapore, Grant/Award Number: NRF‐CRP26‐2021‐0002. 2024-04-08T03:34:09Z 2024-04-08T03:34:09Z 2024 Journal Article Ma, Z., Sun, Z., Ye, Z., Cai, K., Zhong, W., Yuan, W., Zhang W., Zhang, W., Zhang, J., Liang, H., Han, H. & Zhao, Y. (2024). Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer. SmartMat, e1276-. https://dx.doi.org/10.1002/smm2.1276 2688-819X https://hdl.handle.net/10356/174704 10.1002/smm2.1276 2-s2.0-85182832485 e1276 en NRF‐CRP26‐2021‐0002 SmartMat © 2024 The Authors. SmartMat published by Tianjin University and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
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Chemistry Deep penetration Tumor dissociation Ma, Zhaoyu Sun, Zhiduo Ye, Zhichao Cai, Kai Zhong, Wenbin Yuan, Wei Zhang W. Zhang, Weiyun Zhang, Jin Liang, Huageng Han, Heyou Zhao, Yanli Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
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Frequent intravesical chemotherapy is still the adopted clinical option after bladder cancer surgery with low adhesion, poor selectivity, low permeability, and drug resistance. Herein, we develop an ingenious bladder cancer dissociation method to enhance intravesical chemotherapy and tumor self-exclusion with urine. Ethylene diamine tetraacetic acid (EDTA), a common Ca2+ chelator, is loaded with the typical clinical bladder instillation drug doxorubicin (Dox) in chitosan-modified hollow gold nanorods and subsequently coated with cancer cell membranes. After bladder perfusion, the nanoplatform exhibits high affinity toward bladder tumors under homologous targeting, assisting in long-term retention. Under NIR-II laser irradiation, the photothermal effect accelerates the unloading of cargo, and the released EDTA then disrupts intratumoral junctions by depriving and chelating Ca2+ from the intercellular calcium-dependent connexin. The consequential intertumoral dissociation gives access to the deeper penetration of Dox and allows the exclusion of the shed small tumor masses from the body with the urine. This distinctive tumor dissociation concept holds great promise for modern clinical intravesical chemotherapy and perhaps for other gastrointestinal malignancies. |
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School of Chemistry, Chemical Engineering and Biotechnology |
author_facet |
School of Chemistry, Chemical Engineering and Biotechnology Ma, Zhaoyu Sun, Zhiduo Ye, Zhichao Cai, Kai Zhong, Wenbin Yuan, Wei Zhang W. Zhang, Weiyun Zhang, Jin Liang, Huageng Han, Heyou Zhao, Yanli |
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Article |
author |
Ma, Zhaoyu Sun, Zhiduo Ye, Zhichao Cai, Kai Zhong, Wenbin Yuan, Wei Zhang W. Zhang, Weiyun Zhang, Jin Liang, Huageng Han, Heyou Zhao, Yanli |
author_sort |
Ma, Zhaoyu |
title |
Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
title_short |
Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
title_full |
Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
title_fullStr |
Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
title_full_unstemmed |
Tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
title_sort |
tumor cell dissociation-enhanced intravesical chemotherapy of orthotopic bladder cancer |
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2024 |
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https://hdl.handle.net/10356/174704 |
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