LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase

• المؤلفون الرئيسيون: Zeng, Judeng, Xie, Chuan, Huang, Ziheng, Cho, Chi H., Chan, Hung, Li, Qing, Ashktorab, Hassan, Smoot, Duane T., Wong, Sunny Hei, Yu, Jun, Gong, Wei, Liang, Cong, Xu, Hongzhi, Chen, Huarong, Liu, Xiaodong, Wu, Justin C. Y., Ip, Margaret, Gin, Tony, Zhang, Lin, Chan, Matthew T. V., Hu, Wei, Wu, William K. K.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Messenger RNA; Bacterium adherence
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/174911

The role of N6-methyladenosine (m6A) modification of host mRNA during bacterial infection is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A methylases and increases m6A levels in gastric epithelial cells. Reducing m6A methylase activity via hemizygotic deletion of met...