LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase

• Main Authors: Zeng, Judeng, Xie, Chuan, Huang, Ziheng, Cho, Chi H., Chan, Hung, Li, Qing, Ashktorab, Hassan, Smoot, Duane T., Wong, Sunny Hei, Yu, Jun, Gong, Wei, Liang, Cong, Xu, Hongzhi, Chen, Huarong, Liu, Xiaodong, Wu, Justin C. Y., Ip, Margaret, Gin, Tony, Zhang, Lin, Chan, Matthew T. V., Hu, Wei, Wu, William K. K.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Messenger RNA; Bacterium adherence
• Online Access: https://hdl.handle.net/10356/174911
• Institution: Nanyang Technological University

The role of N6-methyladenosine (m6A) modification of host mRNA during bacterial infection is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A methylases and increases m6A levels in gastric epithelial cells. Reducing m6A methylase activity via hemizygotic deletion of met...