A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices

Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons f...

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Main Authors: Basson, Nicol, Peng, Chao-Hong Surachai, Geoghegan, Patrick, van der Lecq, Tshilidzi, Steven, David, Williams, Susan, Lim, An Eng, Ho, Wei Hua
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/174943
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1749432024-04-20T16:49:33Z A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices Basson, Nicol Peng, Chao-Hong Surachai Geoghegan, Patrick van der Lecq, Tshilidzi Steven, David Williams, Susan Lim, An Eng Ho, Wei Hua School of Mechanical and Aerospace Engineering Bioprocessing Technology Institute, A*STAR Engineering Ahmed valve Anterior eye chamber Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons for ECD with one being an induced increase in shear on the corneal wall. A computational fluid dynamics (CFD) model was used to investigate this hypothesis in silico. The Ahmed Glaucoma Valve (AGV) was selected as the subject of this study using an idealised 3D model of the anterior chamber with insertion angles and positions that are commonly used in clinical practice. It was found that a tube-cornea distance of 1.27 mm or greater does not result in a wall shear stress (WSS) above the limit where ECD could occur. Similarly, a tube-cornea angle of 45° or more was shown to be preferable. It was also found that the ECD region has an irregular shape, and the aqueous humour flow fluctuates at certain insertion angles and positions. This study shows that pathological amounts of WSS may occur as a result of certain GDD placements. Hence, it is imperative to consider the associated fluid force interactions when performing the GDD insertion procedure. Published version 2024-04-17T00:49:14Z 2024-04-17T00:49:14Z 2024 Journal Article Basson, N., Peng, C. S., Geoghegan, P., van der Lecq, T., Steven, D., Williams, S., Lim, A. E. & Ho, W. H. (2024). A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices. Scientific Reports, 14(1), 3777-. https://dx.doi.org/10.1038/s41598-023-50491-9 2045-2322 https://hdl.handle.net/10356/174943 10.1038/s41598-023-50491-9 38355702 2-s2.0-85185253306 1 14 3777 en Scientific Reports © The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering
Ahmed valve
Anterior eye chamber
spellingShingle Engineering
Ahmed valve
Anterior eye chamber
Basson, Nicol
Peng, Chao-Hong Surachai
Geoghegan, Patrick
van der Lecq, Tshilidzi
Steven, David
Williams, Susan
Lim, An Eng
Ho, Wei Hua
A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
description Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons for ECD with one being an induced increase in shear on the corneal wall. A computational fluid dynamics (CFD) model was used to investigate this hypothesis in silico. The Ahmed Glaucoma Valve (AGV) was selected as the subject of this study using an idealised 3D model of the anterior chamber with insertion angles and positions that are commonly used in clinical practice. It was found that a tube-cornea distance of 1.27 mm or greater does not result in a wall shear stress (WSS) above the limit where ECD could occur. Similarly, a tube-cornea angle of 45° or more was shown to be preferable. It was also found that the ECD region has an irregular shape, and the aqueous humour flow fluctuates at certain insertion angles and positions. This study shows that pathological amounts of WSS may occur as a result of certain GDD placements. Hence, it is imperative to consider the associated fluid force interactions when performing the GDD insertion procedure.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Basson, Nicol
Peng, Chao-Hong Surachai
Geoghegan, Patrick
van der Lecq, Tshilidzi
Steven, David
Williams, Susan
Lim, An Eng
Ho, Wei Hua
format Article
author Basson, Nicol
Peng, Chao-Hong Surachai
Geoghegan, Patrick
van der Lecq, Tshilidzi
Steven, David
Williams, Susan
Lim, An Eng
Ho, Wei Hua
author_sort Basson, Nicol
title A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
title_short A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
title_full A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
title_fullStr A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
title_full_unstemmed A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
title_sort computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
publishDate 2024
url https://hdl.handle.net/10356/174943
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