High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo

• المؤلفون الرئيسيون: Ragunathan, Priya, Sae-Lao, Patcharaporn, Hamela, Claire, Alcaraz, Matthéo, Krah, Alexander, Poh, Wee Han, Pee, Carmen Jia Ern, Lim, Albert Yick Hou, Rice, Scott A., Pethe, Kevin, Bond, Peter J., Dick, Thomas, Kremer, Laurent, Bates, Roderick Wayland, Grüber, Gerhard
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Medicine, Health and Life Sciences; Mycobacteria; Nontuberculosis mycobacterium
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/175508

The F1FO-ATP synthase engine is essential for viability and growth of nontuberculous mycobacteria (NTM) by providing the biological energy ATP and keeping ATP homeostasis under hypoxic stress conditions. Here, we report the discovery of the diarylquinoline TBAJ-5307 as a broad spectrum anti-NTM...