Understanding the toxicological effects of nanoparticles extracted from sunscreens on human keratinocytes and skin explants

• Main Author: Kwek, Darien Yu De
• Other Authors: Ng Kee Woei
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Engineering; Titanium dioxide; Nanoparticles; Sunscreen; Nanotoxicology; Skin explants; Keratinocytes; Engineered nanomaterials
• Online Access: https://hdl.handle.net/10356/175588
• Institution: Nanyang Technological University

Inorganic ultraviolet filters such as titanium dioxide nanoparticles are frequently utilized in sunscreens. Numerous in vitro and in vivo toxicological studies have been conducted using pristine standard reference nanomaterials of these inorganic filters. While convenient, this approach is not realistic as the complex sunscreen formulation environment could transform the physicochemical properties of the nanoparticles and lead to vastly different toxicological outcomes. Therefore, this study focused on characterizing real sunscreen-extracted nanoparticles and evaluating the associated toxicological impacts upon exposure to human keratinocytes and human skin explants.