The effects of incremental solid stress compression on mechano-sensitive targets and its role in breast cancer malignancy

• Main Author: Muhammad Farouq Bin Azizan
• Other Authors: Koh Cheng Gee
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences; Solid stress; Breast cancer
• Online Access: https://hdl.handle.net/10356/175756
• Institution: Nanyang Technological University

As a tumour mass rapidly expands and pushes on the surrounding host tissues within a finite space, an equal and externally applied force known as solid stress is returned on the tumour mass. Studies have found that solid stress compression induces molecular signalling cascades such as the Akt-GSK-3β...