Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel
The escalating demand for sustainable biomedical materials has steered research towards the valorization of aquaculture waste. This project aims to solve the problem of underutilization of aquatic waste and market gap of photoresponsive collagen based hydrogel via the development of hydrogels...
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sg-ntu-dr.10356-1759272024-05-11T16:45:57Z Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel Tan, Lishan Dalton Tay Chor Yong School of Materials Science and Engineering cytay@ntu.edu.sg Medicine, Health and Life Sciences Hydrogel Sustainability Biomedical The escalating demand for sustainable biomedical materials has steered research towards the valorization of aquaculture waste. This project aims to solve the problem of underutilization of aquatic waste and market gap of photoresponsive collagen based hydrogel via the development of hydrogels derived from collagen of bullfrog skin for potential medical applications. The main aim is to develop biocompatible hydrogel with stable physicochemical properties to meet the market requirements in the biomedical field. To achieve this, a rigorous methodological approach was undertaken, which includes dual-modification of the extracted bullfrog collagen via methacrylation and diamine conjugation, as well as subsequent photocrosslinking to form the a stable hydrogel. The modification process was optimized through a series of experimental phases, assessing the dual modification potential and the sequential effects on the collagen matrix's physical and biological characteristics. Results from this project outlined a success in dual modification optimized for improved physical structural integrity as well as chemical and thermal stability under physiological conditions over 21 days, which could promote wound recovery when applied as dressing materials. The research ultimately proved that stable hydrogels from aquaculture waste collagen could be fabricated. Further research is recommended in refining the modification procedure and hydrogel precursor formulation such that cellular compatibility can be improved, and 3D printability of such hydrogels can be accessed. Bachelor's degree 2024-05-09T08:37:52Z 2024-05-09T08:37:52Z 2024 Final Year Project (FYP) Tan, L. (2024). Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/175927 https://hdl.handle.net/10356/175927 en application/pdf Nanyang Technological University |
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Medicine, Health and Life Sciences Hydrogel Sustainability Biomedical Tan, Lishan Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
description |
The escalating demand for sustainable biomedical materials has steered research
towards the valorization of aquaculture waste. This project aims to solve the problem
of underutilization of aquatic waste and market gap of photoresponsive collagen based
hydrogel via the development of hydrogels derived from collagen of bullfrog skin for
potential medical applications. The main aim is to develop biocompatible hydrogel
with stable physicochemical properties to meet the market requirements in the
biomedical field.
To achieve this, a rigorous methodological approach was undertaken, which includes
dual-modification of the extracted bullfrog collagen via methacrylation and diamine
conjugation, as well as subsequent photocrosslinking to form the a stable hydrogel.
The modification process was optimized through a series of experimental phases,
assessing the dual modification potential and the sequential effects on the collagen
matrix's physical and biological characteristics.
Results from this project outlined a success in dual modification optimized for
improved physical structural integrity as well as chemical and thermal stability under
physiological conditions over 21 days, which could promote wound recovery when
applied as dressing materials. The research ultimately proved that stable hydrogels
from aquaculture waste collagen could be fabricated. Further research is recommended
in refining the modification procedure and hydrogel precursor formulation such that
cellular compatibility can be improved, and 3D printability of such hydrogels can be
accessed. |
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Dalton Tay Chor Yong |
author_facet |
Dalton Tay Chor Yong Tan, Lishan |
format |
Final Year Project |
author |
Tan, Lishan |
author_sort |
Tan, Lishan |
title |
Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
title_short |
Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
title_full |
Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
title_fullStr |
Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
title_full_unstemmed |
Improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
title_sort |
improving photo crosslink-ability and structural stability of amphibian-derived methacrylated collagen hydrogel |
publisher |
Nanyang Technological University |
publishDate |
2024 |
url |
https://hdl.handle.net/10356/175927 |
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1800916123008368640 |