An adjuvant micelle-based multifunctional nanosystem for tumor immunotherapy by remodeling three types of immunosuppressive cells

• Main Authors: Meng, Siyu, Du, Huiping, Li, Xiang, Zheng, Xinmin, Zhao, Pan, Yuan, Zhang, Huang, Shaohui, Zhao, Yanli, Dai, Liangliang
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cancer-targeted triple immunotherapy; Drug delivery barriers
• Online Access: https://hdl.handle.net/10356/177904
• Institution: Nanyang Technological University

Immunotherapy is restricted by a complex tumor immunosuppressive microenvironment (TIM) and low drug delivery efficiency. Herein, a multifunctional adjuvant micelle nanosystem (PPD/MPC) integrated with broken barriers and re-education of three classes of immune-tolerant cells is constructed for canc...