Single-site nanozymes with a highly conjugated coordination structure for antitumor immunotherapy via cuproptosis and cascade-enhanced T lymphocyte activity

Single-site nanozymes with a highly conjugated coordination structure for antitumor immunotherapy via cuproptosis and cascade-enhanced T lymphocyte activity

The extracellular matrix (ECM) in the tumor microenvironment (TME) and upregulated immune checkpoints (ICs) on antitumor immune cells impede the infiltration and killing effect of T cells, creating an immunosuppressive TME. Herein, a cholesterol oxidase (CHO) and lysyl oxidase inhibitor (LOX-IN-3) c...

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Bibliographic Details
Main Authors: Liu, Yang, Niu, Rui, Zhao, Huan, Wang, Yinghui, Song, Shuyan, Zhang, Hongjie, Zhao, Yanli
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
Antitumour activity
Cholesterol depletion
Online Access:https://hdl.handle.net/10356/177907
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/177907

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