Silicon-containing thiol-specific bioconjugating reagent

• Main Authors: Zhang, Zhenguo, Li, Lanyang, Xu, Hailun, Lee, Ken Chi-Lik, Jia, Zhenhua, Loh, Teck-Peng
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Antibody conjugate; Thiol derivative
• Online Access: https://hdl.handle.net/10356/177908
• Institution: Nanyang Technological University

A new bioconjugation reagent containing silicon has been developed for the selective reaction with thiols. The inclusion of silicon significantly improves chemoselectivity and suppresses retro processes, thereby exceeding the capabilities of traditional reagents. The method is versatile and compatib...