MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

Emerging data suggest a significant cross-talk between metabolic and epigenetic programs. However, the relationship between the mechanistic target of rapamycin (mTOR), which is a pivotal metabolic regulator, and epigenetic modifications remains poorly understood. Our results show that mTORC1 activat...

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Bibliographic Details
Main Authors: Kim, HaEun, Lebeau, Benjamin, Papadopoli, David, Jovanovic, Predrag, Russo, Mariana, Avizonis, Daina, Morita, Masahiro, Afzali, Farzaneh, Ursini-Siegel, Josie, Postovit, Lynne-Marie, Witcher, Michael, Topisirovic, Ivan
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Medicine, Health and Life Sciences
Epigenetics
Molecular biology
Online Access:https://hdl.handle.net/10356/178388
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/178388

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