Viral peptide conjugates for metal-warhead delivery to chromatin

• Main Authors: Batchelor, Lucinda K., De Falco, Louis, Dyson, Paul J., Davey, Curtis A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Metallopeptides; Nucleosomes
• Online Access: https://hdl.handle.net/10356/178391
• Institution: Nanyang Technological University

The presence of heavy metal groups can endow compounds with unique structural and chemical attributes beneficial for developing highly potent therapeutic agents and effective molecular labels. However, metallocompound binding site specificity is a major challenge that dictates the level of off-site...