PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells

• Main Authors: Groh, Ann-Christin, Möller-Kerutt, Annika, Gilhaus, Kevin, Höffken, Verena, Nedvetsky, Pavel, Kleimann, Simon, Behrens, Malina, Ghosh, Sujasha, Hansen, Uwe, Krahn, Michael P., Ebnet, Klaus, Pavenstädt, Hermann, Ludwig, Alexander, Weide, Thomas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cell junction; Cell polarity
• Online Access: https://hdl.handle.net/10356/178420
• Institution: Nanyang Technological University

The evolutionarily conserved apical Crumbs (CRB) complex, consisting of the core components CRB3a (an isoform of CRB3), PALS1 and PATJ, plays a key role in epithelial cell-cell contact formation and cell polarization. Recently, we observed that deletion of one Pals1 allele in mice results in functio...