Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover

• Main Authors: Foo, Mattheus Xing Rong, Ong, Peh Fern, Yap, Zi Xuan, Maric, Martina, Bong, Christopher Jue Shi, Dröge, Peter, Burke, Brian, Dreesen, Oliver
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; DNA damage; Farnesyltransferase inhibitor
• Online Access: https://hdl.handle.net/10356/178571
• Institution: Nanyang Technological University

Hutchinson-Gilford Progeria syndrome (HGPS) is a severe premature ageing disorder caused by a 50 amino acid truncated (Δ50AA) and permanently farnesylated lamin A (LA) mutant called progerin. On a cellular level, progerin expression leads to heterochromatin loss, impaired nucleocytoplasmic transport...