Computational modeling of light processing in the habenula and dorsal raphe based on laser ablation of functionally-defined cells

• Main Authors: Cheng, Ruey-Kuang, Jagannathan, N. Suhas, Kathrada, Ahmad Ismat, Jesuthasan, Suresh, Tucker-Kellogg, Lisa
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Neural circuits; Computational modelling
• Online Access: https://hdl.handle.net/10356/178842
• Institution: Nanyang Technological University

Background: The habenula is a major regulator of serotonergic neurons in the dorsal raphe, and thus of brain state. The functional connectivity between these regions is incompletely characterized. Here, we use the ability of changes in irradiance to trigger reproducible changes in activity in the ha...