Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex

• Main Authors: Zeng, Jialiu, Loi, Gavin Wen Zhao, Saipuljumria, Eka Norfaishanty, Duránc, Marco Antonio Romero, Silva-García, Octavio, Perez-Aguilard, Jose Manuel, Baizabal-Aguirre, Víctor M., Lo, Chih Hung
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2024
• 主題: Medicine, Health and Life Sciences; TNFR1 signaling; Conformational dynamics
• 在線閱讀: https://hdl.handle.net/10356/179004

Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF induced downstream signaling and regulating inflammatory response. Recent studies have suggested that TNFR1 activation involves conformational rearrangements of preligand assembled receptor dimers and targeting rece...