Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor-ligand signaling complex
Tumor necrosis factor (TNF) receptor 1 (TNFR1) plays a pivotal role in mediating TNF induced downstream signaling and regulating inflammatory response. Recent studies have suggested that TNFR1 activation involves conformational rearrangements of preligand assembled receptor dimers and targeting rece...
Saved in:
Main Authors: | Zeng, Jialiu, Loi, Gavin Wen Zhao, Saipuljumria, Eka Norfaishanty, Duránc, Marco Antonio Romero, Silva-García, Octavio, Perez-Aguilard, Jose Manuel, Baizabal-Aguirre, Víctor M., Lo, Chih Hung |
---|---|
Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2024
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/179004 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Similar Items
-
TNF RECEPTOR 1 SIGNALING IN CEREBROVASCULAR DISEASE AND NEURODEGENERATION
by: SALAI KAUNG HTET TUN
Published: (2023) -
Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling
by: Moh, M.C., et al.
Published: (2014) -
Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor
by: Pang, Kuin Tian, et al.
Published: (2022) -
Coherent conformational degrees of freedom as a structural basis for allosteric communication
by: Mitternacht S., et al.
Published: (2019) -
GRATITUDE AND CONFORMITY: DOES GRATITUDE INCREASE CONFORMITY TO GROUP PREJUDICIAL NORMS?
by: KWEK MEI YIN
Published: (2018)