Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy
A nano-immunomodulator (R-NPT NP) comprising a tumor microenvironment (TME) activable resiquimod (R848) and a π-extended NIR-absorbing naphthophenanthrolinetetraone (NPT) has been engineered for spatiotemporal controlled photothermal immunotherapy. R-NPT NP demonstrated excellent photostability, whi...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2024
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/179257 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-179257 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1792572024-07-23T07:06:25Z Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy Zhong, Wenbin Yuan, Wei Chen, Yun Ma, Zhaoyu Ma, Mengmeng Tan, Brynne Shu Ni Yang, Jie Zhao, Yanli School of Chemistry, Chemical Engineering and Biotechnology Medicine, Health and Life Sciences Glutathione activable effect Photothermal immunotherapy A nano-immunomodulator (R-NPT NP) comprising a tumor microenvironment (TME) activable resiquimod (R848) and a π-extended NIR-absorbing naphthophenanthrolinetetraone (NPT) has been engineered for spatiotemporal controlled photothermal immunotherapy. R-NPT NP demonstrated excellent photostability, while R848 promoted synergistic immunity as a toll-like receptor 7/8 (TLR7/8) agonist. Upon accumulation at the tumor site, R-NPT NP released R848 in response to redox metabolite glutathione (GSH), triggering dendritic cell (DC) activation. The photothermal effect endowed by R-NPT NP can ablate tumors directly and trigger immunogenic cell death to augment immunity after photoirradiation. The synergistic effect of GSH-liable TLR7/8 agonist and released immunogenic factors leads to a robust evocation of systematic immunity through promoted DC maturation and T cell infiltration. Thus, R-NPT NP with photoirradiation achieved 99.3 % and 98.2 % growth inhibition against primary and distal tumors, respectively. National Research Foundation (NRF) This work was supported by the National Research Foundation Singapore under its Competitive Research Programme (NRF-CRP26-2021-0002). 2024-07-23T07:06:24Z 2024-07-23T07:06:24Z 2024 Journal Article Zhong, W., Yuan, W., Chen, Y., Ma, Z., Ma, M., Tan, B. S. N., Yang, J. & Zhao, Y. (2024). Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy. Angewandte Chemie International Edition, 63(23), e202401250-. https://dx.doi.org/10.1002/anie.202401250 1433-7851 https://hdl.handle.net/10356/179257 10.1002/anie.202401250 38576254 2-s2.0-85191830169 23 63 e202401250 en NRF-CRP26-2021-0002 Angewandte Chemie International Edition © 2024 Wiley-VCH GmbH. All rights reserved. |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Medicine, Health and Life Sciences Glutathione activable effect Photothermal immunotherapy |
spellingShingle |
Medicine, Health and Life Sciences Glutathione activable effect Photothermal immunotherapy Zhong, Wenbin Yuan, Wei Chen, Yun Ma, Zhaoyu Ma, Mengmeng Tan, Brynne Shu Ni Yang, Jie Zhao, Yanli Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
description |
A nano-immunomodulator (R-NPT NP) comprising a tumor microenvironment (TME) activable resiquimod (R848) and a π-extended NIR-absorbing naphthophenanthrolinetetraone (NPT) has been engineered for spatiotemporal controlled photothermal immunotherapy. R-NPT NP demonstrated excellent photostability, while R848 promoted synergistic immunity as a toll-like receptor 7/8 (TLR7/8) agonist. Upon accumulation at the tumor site, R-NPT NP released R848 in response to redox metabolite glutathione (GSH), triggering dendritic cell (DC) activation. The photothermal effect endowed by R-NPT NP can ablate tumors directly and trigger immunogenic cell death to augment immunity after photoirradiation. The synergistic effect of GSH-liable TLR7/8 agonist and released immunogenic factors leads to a robust evocation of systematic immunity through promoted DC maturation and T cell infiltration. Thus, R-NPT NP with photoirradiation achieved 99.3 % and 98.2 % growth inhibition against primary and distal tumors, respectively. |
author2 |
School of Chemistry, Chemical Engineering and Biotechnology |
author_facet |
School of Chemistry, Chemical Engineering and Biotechnology Zhong, Wenbin Yuan, Wei Chen, Yun Ma, Zhaoyu Ma, Mengmeng Tan, Brynne Shu Ni Yang, Jie Zhao, Yanli |
format |
Article |
author |
Zhong, Wenbin Yuan, Wei Chen, Yun Ma, Zhaoyu Ma, Mengmeng Tan, Brynne Shu Ni Yang, Jie Zhao, Yanli |
author_sort |
Zhong, Wenbin |
title |
Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
title_short |
Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
title_full |
Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
title_fullStr |
Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
title_full_unstemmed |
Activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
title_sort |
activable nano-immunomodulator assembled from π-extended naphthalenediimide for precision photothermal immunotherapy |
publishDate |
2024 |
url |
https://hdl.handle.net/10356/179257 |
_version_ |
1814047384523505664 |